2024 Klotho genecard

Klotho genecard

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August undefined, 2024

WebAbstract. The klotho gene was originally identified as a putative age-suppressing gene in mice that extends life span when overexpressed. It induces complex phenotypes resembling human premature aging syndromes when disrupted. The gene was named after a Greek goddess Klotho who spun the thread of life. Since then, various functional aspects of ... WebFeb 20, 2024 · Klotho is a protein encoded by the klotho gene (Figure 1). The klotho protein can exist in either a membrane-bound form or a secreted, soluble form. The membrane-bound form is produced when the ...

KLB klotho beta [Homo sapiens (human)] - Gene - NCBI

WebMar 12, 2024 · α-Klotho is a geroprotective factor that exerts anti-physiological stress effects and protects against oxidative damage, hypoxia, and cytotoxic drugs., Soluble α-Klotho is an endocrine protein that regulates multiple biological processes, including phosphate homeostasis, mineral metabolism, and signaling by insulin-like growth factor 1 … WebMay 20, 2024 · The KLOTHO gene affects a protein found in the kidneys and the brain that regulates many different body processes. About one in five people carry a single copy of the variant, known as KL-VS, which boosts levels of the protein and is associated with a longer lifespan and improved heart and kidney function. A small minority, 3% of the population ... golf fairway woods

Factors That Increase Klotho (Protein) + Gene …

WebAug 8, 2024 · Klotho weaves them all together (yes, another ‘thread’ pun). Klotho levels and mortality. In humans, klotho levels have been shown to predict mortality. A six-year-long study of 804 adults aged 65 or older found that those with lower klotho levels had a 78% greater mortality risk. Lower klotho levels were defined as being in the bottom 25%. WebNov 19, 2024 · The Klotho protein that was identified as the FGF23 co-receptor became known as αKlotho (encoded by the αKlotho gene; also known as KL ). βKlotho forms … WebJul 27, 2011 · The Klotho peptide generated by cleavage of the membrane-bound isoform may be an anti-aging circulating hormone which would extend life span by inhibiting … health aid calmagzinc tablet oral

Klotho Variant Cuts ApoE4’s Alzheimer Risk by a Third

Frontiers The impact of SGLT2 inhibitors on αKlotho in renal …

WebFeb 6, 2024 · The klotho (kl) gene was identified as a regulator of normal ageing, where mutated forms led to accelerated ageing phenotypes. Therefore, klotho can be considered as an ‘ageing-suppressor’ gene. WebDefinition of klotho in the Definitions.net dictionary. Meaning of klotho. What does klotho mean? Information and translations of klotho in the most comprehensive dictionary … golf fairway wood coversWebApr 1, 2015 · The Klotho ( KL) gene encodes the α-Klotho protein. Information about the KL gene and its protein is provided in Table 1. The KL gene was identified by Kuro-o et al ( 1) in 1997 through a spontaneous mutation of the α-Klotho promoter region of α-Klotho. The mouse KL gene locus is located on chromosome 5 ( Figure 1) and flanked by PDS5B and … health aid calcium

"WebAug 27, 2024 · Klotho has been recognized as a gene involved in the aging process in mammals for over 30 years, where it regulates phosphate homeostasis and the activity of … " - Klotho genecard

Klotho genecard

KL klotho [Homo sapiens (human)] - Gene - NCBI

WebAug 10, 2024 · Klotho protects the kidney and promotes phosphate elimination. Remarkably, independent of FGF23, it inhibits at least four pathways that have been linked to aging in various ways. Klotho blocks or inhibits transforming growth factor β (TGF-β), insulin-like growth factor 1 (IGF-1), nuclear factor κB (NF-κB), and Wnt/β-catenin . WebMar 21, 2024 · GeneCards Summary for KLB Gene. KLB (Klotho Beta) is a Protein Coding gene. Diseases associated with KLB include Functional Diarrhea and Epilepsy, Idiopathic …

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WebJan 21, 2024 · Klotho is an anti-ageing protein whose expression is downregulated in chronic kidney disease, but the large size of the protein makes it challenging to deliver … WebApr 4, 2024 · KL klotho [ Homo sapiens (human) ] Gene ID: 9365, updated on 21-Mar-2024 Download Datasets Summary Official Symbol KL provided by HGNC Official Full Name …

WebApr 4, 2024 · Klotho is expressed in the human heart and its expression level is mediated by TGF-beta1, is associated with the degree of chronic kidney disease and cardiac fibrosis. … WebApr 14, 2024 · Klotho is a renal protein antioxidant found in mammals that was first identified in 1997. When there was a defect in expression of the gene for Klotho, lab animals aged quickly and died prematurely. Overexpression of the Klotho gene resulted in lab animals living unexpectedly long lives.

WebDec 15, 2024 · Klotho is a protein that circulates in the blood and brain throughout life. It declines with age, in conjunction with cognitive deficits [ 1, 2, 3, 4 ]. According to some research, it plays a role in longevity [ 5, 6 ]. It … WebMar 21, 2024 · KL (Klotho) is a Protein Coding gene. Diseases associated with KL include Tumoral Calcinosis, Hyperphosphatemic, Familial, 3 and Tumoral Calcinosis, … TRPV1 (Transient Receptor Potential Cation Channel Subfamily V Member 1) is a … AKT1 is one of 3 closely related serine/threonine-protein kinases (AKT1, … FGF2 (Fibroblast Growth Factor 2) is a Protein Coding gene. Diseases … Complete information for ENSG00000230490 gene (RNA Gene), … Complete information for TOMM22P3 gene (Pseudogene), TOMM22 Pseudogene 3, … Complete information for RNY1P4 gene (Pseudogene), RNY1 Pseudogene 4, …

WebNov 9, 2024 · Klotho production in peripheral organs is highest in the kidney where it regulates vitamin D metabolism and the transport of phosphate and calcium (8, 11).Alternative splicing gives rise to two isoforms: secreted klotho (s-KL, amino acids 1 to 550 in mice) and full-length transmembrane klotho (m-KL, amino acids 1 to 1014 in mice) …

WebApr 17, 2024 · Klotho is named for the Greek goddesses who spins the threads of mythological life. The gene has puzzled scientists since it revealed itself to be involved in longevity in 1997. Its protein regulates biology in multiple organs, including the brain, where it seems to enhance learning and memory ( May 2014 news ). golf fairway wood swing tipsWebOct 11, 2005 · Description. A form of hyperphosphatemic tumoral calcinosis, a rare autosomal recessive metabolic disorder that manifests with hyperphosphatemia and massive calcium deposits in the skin and subcutaneous tissues. Some patients have recurrent, transient, painful swellings of the long bones associated with the radiographic … golf fairway woods head coversWebThe KL gene provides instructions for making the protein alpha-klotho, which is found primarily in kidney cells. This protein plays a major role in regulating the phosphate levels … healthaid children\u0027s probioticsWebMay 11, 2024 · Klotho deficiency in Osx +-cells causes impaired bone remodeling. a, c Three-dimensional reconstruction from micro-computed tomography scans of the alveolar bone of OsxCre;KL fl/fl mice and their ... golf fairway woods setWebGenes names: Klotho; Klotho Beta; Pathways: FGFR1c and Klotho ligand binding and activation golf falcon hudsonWebMar 8, 2024 · Canagliflozin and sotagliflozin, however, increased Klotho protein concentration in the cell culture supernatant, an effect possibly due to up-regulation of ADAM17. Taken together, our investigations demonstrate complex effects of different SGLT2 inhibitors on αKlotho gene expression and protein secretion in renal MDCK and HK … golf false frontReduced α-klotho or FGF23 can result in impaired phosphate excretion from the kidney, leading to hyperphosphatemia. In mice, this leads to a phenotype characteristic of premature aging, which can be mitigated by feeding the mice a low phosphate diet. The plasma (soluble) form of α-klotho is most easily measured, and has been shown to decrease after 40 years of age in humans. Lower plasma levels of α-klotho in older adults is associated wi… healthaid colonease